You should never vacuum rodent droppings in your attic because vacuuming can send contaminated particles into the air

https://chancenllf843.keystonescope.com/posts/why-sealing-your-eaves-is-the-secret-to-a-rat-free-attic-in-san-diego-2

You should never vacuum rodent droppings in your attic because vacuuming can send contaminated particles into the air and raise the risk of exposure to rodent-borne diseases.